Antidepressants lower the risk of suicide attempt in adults with depression, as per a research studyreported in the recent issue of the American Journal of Psychiatry. The scientists also observed that the lower risk held true for young adults ages 18 to 25.

"The risk of suicide attempt among depressed patients treated with SSRI drugs was about one-third that of patients who were not treated with an SSRI," said the lead author Robert Gibbons, director of the Center for Health Statistics and professor of biostatistics and psychiatry at the University of Illinois at Chicago. "We would not expect a lower risk in this patient population because patients treated with SSRIs are generally more severely depressed and would have a higher risk of suicide attempt".

The scientists analyzed medical data of 226,866 patients newly diagnosed with depression in 2003 or 2004 at the Veterans Administration healthcare system. They compared risk of suicide in four age groups (ages 18 to 25; 26 to 45; 46 to 65; and older than 65) before and after therapy with selective serotonin reuptake inhibitor medications, also known as SSRI drugs.

All age groups of depressed patients who received selective serotonin reuptake inhibitors -- the most usually prescribed antidepressant medicine -- showed a significantly lower risk of suicide attempt when in comparison to those who did not receive antidepressant therapy.

Among 82,828 patients, there were 183 suicide attempts before therapy with SSRI drugs and 102 suicide attempts after therapy with SSRI drugs (a rate that fell from 221 to 123 per 100,000 after therapy).

In 2004, the Food and Drug Administration issued a black box warning suggesting that SSRI drugs increase the risk of suicidal behavior in children and adolescents. An FDA advisory committee recently recommended extending this black box warning to young adults.

Gibbons cautions that extending this warning to young adults may further decrease antidepressant therapy of depression and contribute to higher rates of suicide.

In prior research, Gibbons reported an inverse relationship between antidepressant prescriptions and the rates of suicide in children and adolescents.


Posted by: Rose    Source

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